Tru Niagen: Age Smarter From the Inside Out


Energy is what keeps our bodies going, and mitochondria are crucial in creating energy for our cells. Many different chemical reactions and coenzymes are at play, namely one critical molecule known as nicotinamide adenine dinucleotide, NAD+ for short.

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Nicotinamide riboside is a groundbreaking ingredient that fuels your body from within.



NAD+ is like the mitochondrion’s most reliable friend, constantly delivering charged electrons to produce bountiful ATP in the electron transport chain.  Unfortunately, the amount of NAD+ we produce naturally declines with age.  A study published in Physiological Reports shows that exercise training can naturally increase NAD+ levels.  Conversely, things like age, metabolic stress, immune stress, drinking, overeating can all contribute to NAD+ depletion.



In pursuit of understanding the science of aging and how to best manage it, the scientific community has put a large focus on NAD+ research and its relationship to mitochondrial dysfunction. It’s widely accepted that mitochondrial health plays a huge part in our overall human health and NAD+ is part of that story.

Not surprisingly, NAD+ depletion has emerged as a fundamental feature of cellular dysfunction and aging, with a growing body of evidence linking its declining levels to aging and a variety of health conditions.  Niagen® nicotinamide riboside (NR) is clinically proven to boost NAD+, making it an important health optimization tool at the cellular level. By increasing NAD+, Niagen® promotes mitochondrial health to support the body’s natural energy production mechanisms. It has been reviewed and accepted for safety by the leading regulatory bodies in the world, validating it as a trusted key ingredient in Tru Niagen®.

The objective proof behind Niagen® in 11 published human clinical studies

Niagen®'s human clinical studies provide the foundation of scientific evidence. Researchers use Niagen® (patented nicotinamide riboside) as the preferred cellular nutrient for elevating NAD+ levels.

Check out Niagen®'s study on elevation in NAD+ levels here.





Additional Technical Overview Information:

WHO defines healthy aging as “the process of developing and maintaining the functional ability enabling well-being in older age. Functional ability includes all health-related attributes enabling people to be and do what they value. It is determined by the composite of all physical and mental capacities of an individual, the external experiences that form the context of a person’s life, and the interactions between the two. Collectively, these factors define what is known as intrinsic capacity (IC).  Specifically, IC is an indicator of our body’s ability to maintain vital functions in the face of stress, whether it is aging, poor diet, lack of sleep, a sedentary lifestyle, or immune stress. It is a direct indicator of health. The better an individual responds to stressors, the more resilient they are, and such, the better their overall health status. The same is the case at the cellular level, and nicotinamide adenine dinucleotide (NAD+) is a primary factor in cells’ IC or resilience.

NAD+ plays a critical role in maintaining healthy mitochondrial and cellular function, activating DNA repair mechanisms, and helping resist the effects of cellular stressors. It is found in every living cell where it drives cellular energy production in the mitochondria and serves as an important signaling molecule for cellular maintenance and repair. Optimizing healthy mitochondrial function and bolstering cellular maintenance and repair are central to maintaining an individual’s IC.

The publication of the first clinical trial of Niagen® in 2016 opened the door to new research assessing NR’s ability to address many of the common conditions and challenges associated with aging. With more than 40 registered Niagen® clinical trials and new preclinical studies publishing monthly, NR has gained prominence in the scientific community as a safe and
effective way to increase NAD+ to promote ongoing cellular health over time.

Mechanism Of Action

NR is an NAD+ precursor that is structurally related to niacin and nicotinamide. It is transported directly into cells via nucleoside transporters, where it is converted to NAD+ through a unique two-step biosynthetic pathway. NR raises intracellular NAD+ levels with superior pharmacokinetics compared to both niacin, nicotinamide, and nicotinamide mononucleotide (NMN). Research on NMN, a known NR and NAM provitamin and NAD+ precursor, has also emerged.  Multiple studies have demonstrated that NMN must be extracellularly converted to NR to increase cellular NAD+. The phosphate group on NMN is removed by the extracellular enzyme CD73, thereby converting NMN into NR. By increasing NAD+ levels, NR promotes mitochondrial health, supporting the body’s natural energy production mechanisms and promoting healthy aging.

NR Is A Unique NAD+ Precursor.  In addition to using a novel pathway to synthesize NAD+, NR has several unique features that differentiate it from the other vitamin B3s. Most notably, NR does not cause the same uncomfortable flushing response commonly triggered by high-dose NA supplementation. NA induces flushing through activation of the G-protein coupled receptor GPR109A.[93] NR does not interact with this receptor and has not been shown to cause flushing in clinical trials of doses as high as 2,000 mg/day.